NMR (Nuclear Magnetic Resonance) Spectroscopy

NMR (Nuclear Magnetic Resonance) Spectroscopy provides physical, chemical, electronic and structural information from organic compounds in liquid or solid form.

Samples are typically dissolved in a deuterium-labelled solvent to form, a clear solution before being transferred to a thin, transparent glass NMR tube. The sample is then placed into a very strong magnetic field whereby the nuclei of the atoms absorb and then re-emit electromagnetic radiation at a particular resonance frequency.  This information provides structural and electronic information which translates into an extremely powerful analytical technique.

Nuclear Magnetic Resonance Spectroscopy offers:

  • Identification of molecular chemical environments and structures
  • Physical and chemical properties at the atomic and molecular level
  • Well resolved, highly sensitive, analytically tractable and highly predictable analysis.

Typical Applications

  • Structural determination of molecules including biomacromolecules
  • Determination of molecular motion and interaction profiles
  • The study of proteins including enzyme active sites
  • Compound identification
  • Purity analysis
  • Stability studies.

Typical Industries using NMR Spectroscopy:

  • Pharmaceutical industry
  • Agrochemical industry
  • Chemical industry
  • Polymer industry
  • Medical device industry
  • Nuclear industry
  • Consumer health
  • Packaging manufacturers
  • Petrochemical and oil.

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  • NMR Spectroscopy - At a Glance

    • Information: Molecular information of simple and complex structures, normally relates to a single element
    • Sample Prerequisites: Understanding the material so that appropriate solvent can be used as required
    • Typical samples: Organic, inorganic or biochemical molecules
    • Output: Separation by functional groups and differing neighbouring groups, plus relative quantities of elements present
    • Sample Size: Sample sizes of less than 1g are required
    • Detection Limits: NMR has limited sensitivity to minor components
    • Data Output: Spectrum of signal intensity against chemical shift
    • Elements Characterized: Analysis is normally limited to a single element, typically hydrogen
    • Samples: Liquids, dissolved solids and solids may be analyzed using the appropriate instrumentation