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Intelligent Controlled Release Technology (iCRT™)

Intelligent Controlled Release Technology (iCRTTM)

iCRTTM offers a solution for controlled release of molecules and ions. The technology is versatile and flexible, able to work in synergy with existing products. iCRT utilises GRAS (Generally Recognised as Safe) materials, and by employing internal expertise and know-how, the material properties of the active ingredient product can be controlled to provide specificity and versatility to meet various application requirements.

iCRTTM works by introducing the relevant active ingredient into an inorganic amorphous matrix which is subsequently released by two key approaches, depending on the desired release: via a soluble matrix, or a porous insoluble matrix.

Intelligent Controlled Release Technology

 

iCRT has been developed by our experts for encapsulation and delivery of actives, including:

  • small and large molecules
  • both organic and inorganic
  • inorganic ions

Our capabilities

Combining the understanding of all steps in material development requires considerable scientific resource and expert knowledge, especially at commercially viable cost points. Embodied in our iCRT technology, we bring together the capability and expertise rarely found in one company: materials science skills, formulation knowledge, and testing know-how.

Porous matrix

A low temperature process is used for the generation of the carrier particles making it ideal for the encapsulation and controlled release of organic actives. Furthermore, the properties of the carrier particles can be designed in order to control the release rate of the ingredient as desired for the specific application required.

Within our existing capabilities and Intellectual Property (IP) associated with this technology, Lucideon is examining novel processing routes for further scale-up in order to provide solutions that are time and cost-effective.

Soluble matrix

Lucideon's proprietary process for producing soluble carrier iCRT particles is best suited for the delivery of active ions. With a wide compositional range available, the potential applications for this technology are wide and varied. It is particularly beneficial in high temperature applications, and the solubility can be tailored for different extremes of pH or ionic strength. Lucideon's expertise in materials science and formulation helps to optimise the performance of these products depending on the client’s needs.

 

Applications

Porous matrix:

  • extended release of active ingredients
  • dissolution rate enhancement of poorly water-soluble active ingredients
  • taste masking of active ingredients with poor consumer tolerance
  • abuse-deterrent formulations of ingredients with potential for dependency or accidental dose dumping
  • encapsulation of protein-based active ingredients

 

Soluble matrix:

  • agricultural Fertiliser
  • use of bioactive glasses to enhance therapeutic activity of medical devices
  • use of bioactive glasses to add therapeutic activity to dental products

 

Abuse deterrent formulations

Abuse deterrent formulations are formulated additions to pharmaceuticals that are designed to prevent the abuse of medications such as opioids by incorporating mechanisms to prevent crushing, snorting, or injecting, while still allowing the drug to provide therapeutic effects.

White Papers

Pharmaceuticals
Abuse Deterrence for the Pharmaceutical Market

This white paper explores the market drivers for abuse deterrence and identifies possible solutions

Protecting Products and Patients in Today's Prescription Drug Abuse Epidemic

In this white paper, we discuss the journey behind Lucideon's proprietary iCRT-deter technology