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Abuse Deterrence

A True Abuse Deterrent Platform Technology

Our abuse deterrent formulation platform technology, iCRT-deter, offers a carrier that protects against abuse methods including: dissolution in most common household solvents, heating and mechanical tampering.

USP Diagram

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iCRT-deter is an advanced controlled release carrier, with a range of release profiles and triggers, that offers powerful abuse deterrent features for potent or addictive compounds, including but not limited to opioids.  Being a highly flexible platform, iCRT-deter's abuse deterrence properties can be applied to multiple routes of administration, including oral, sublingual and parenteral product forms.  iCRT-deter has been tested and proven across a range of compounds of varying solubility levels, and produced tablets are not bulky nor hard to swallow, benefiting the genuine patient.

Varying Solubility

And we have demonstrated in-vitro bioequivalence of our tablet formulation to RLD (Reference Listed Drug).

In Vitro Bioequivalence

The technology deters various routes of abuse, including solvent extraction and injection, via resistance to crushing, chewing, heating, and extraction in alcohol and common household solvents.  iCRT-deter also offers a potential solution to alcohol induced dose-dumping.

Easily formulated into and compatible with existing products to give immediate or extended release, iCRT-deter is a green process that also offers processing protection.

We've developed our platform with your patient in mind:

  • Ease of use.
  • Small, easy-to-swallow tablets.
  • Tablets can be crushed for administration without releasing their APIs


The technology is highly flexible and can be modified depending on your product and application requirements.  It can be used in conjunction with other technologies such as antagonists, and is suitable for both oral and sublingual drug products.  As it is a powder technology with good flow properties, it is easily formulated into existing products.

Get in touch or visit our dedicated website to find out more about how iCRT-deter can help you market safer, more effective products.

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  • White Paper

    Protecting Products and Patients in Today's Prescription Drug Abuse Epidemic
    pdf (481 KB)

  • White Paper

    Abuse Deterrence for the Pharmaceutical Market
    pdf (1.94 MB)

  • Article

    The Prescription Abuse Epidemic: Designing a Solution
    pdf (1.36 MB)

  • Data Sheet

    Tackling Stability and Abuse - iCRT
    pdf (155 KB)