MxHA - Multi-element-substituted Hydroxyapatite

Improving Bioactivity of Hydroxyapatite

We are actively engaged in developing novel and simplified methods for the synthesis of hydroxyapatite (HA) substituted with multi-elements (MxHA). This new technology allows us to design the surface charge potential of the HA crystals and add intrinsic functionality and improved bioactivity to the material through the incorporation of different elements.

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Indication of Bioactivity by Measurement of Surface HA Growth


  • Bone and dental replacement applications
  • Bioactive adhesives/cements
  • Drug delivery systems
  • Encapsulation
  • Fillers.

Our materials experts are currently developing:

  • New and simplified synthetic routes to manufacture HA
  • Multi-element-substituted HA with tailored charge variations via the introduction of different cations and anions into the HA lattice
  • Porous granulates containing crystallites of <100 nm
  • Nano HA crystals
  • Contract R&D and manufacturing of HA and multi-element-substituted HA.

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  • Newsletter

    Medical Devices Newsletter

    pdf 660 KB

  • White paper

    Multi-Substituted Hydroxyapatites & Their Role in Bone Replacement

    pdf 906 KB

  • White paper

    Synthesis Method of Hydroxyapatite

    pdf 1 MB

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